Rare variant genetics and dilated cardiomyopathy severity: The DCM Precision Medicine Study
Jan 1, 2023·,,,,,,,,,,,,,,,,,,,,,,,,,,,,,·
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MD Ray E. Hershberger
MD Mauro Giacca
MD Mark Hofmeyer
MD Garrie J. Haas
MS Elizabeth Jordan
MS Jinwen Cao
MD Evan Kransdorf
PhD Gregory A. Ewald
MD Alanna A. Morris
MSc Anjali Owens Md
M. Lowes
P. Stoller
P. W. Tang
Mamta Garg
Marija Trachtenberg
M. Shah
Michael Sweitzer
P. M. Wheeler
Priya Md
M. S. Katz
M. Pan
M. Md
Pippa Smart
MD Jessica Wang
M. Gottlieb
M. Judge
M. K. Moore
M. Huggins
M. D. D. Kinnamon
P. Ni
Abstract
BACKGROUND: Dilated cardiomyopathy (DCM) can lead to advanced disease, defined herein as necessitating a durable left ventricular assist device or a heart transplant (LVAD/HT). DCM is known to have a genetic basis, but the association of rare variant genetics with advanced DCM has not been studied. METHODS: We analyzed clinical and genetic sequence data from patients enrolled between 2016 and 2021 in the US multisite DCM Precision Medicine Study, which was a geographically diverse, multiracial, multiethnic cohort. Clinical evaluation included standardized patient interview and medical record q…
Type
Publication
Circulation