Genetic Contributions to Early and Late Onset Ischemic Stroke

Jan 1, 2021·
MS Thomas Jaworek
,
MD Huichun Xu
,
P. Gaynor
,
M. Cole
,
MS Kristiina Rannikmäe Md
,
PhD Liisa Tomppo
,
P. Amouyel
,
P. N. D. Armstrong
,
MS John Attia PhD
,
Frcpc Fracp Clin Dip PhD
,
Palliat Med
,
PhD Steven Bell
,
MD Oscar R. Benavente
,
MD Giorgio B. Boncoraglio
,
PhD Adam Butterworth
,
MSc Jara Cárcel-Márquez
,
Zhengming Chen
,
MSc Michael Chong
,
PhD Carlos Cruchaga
,
MSc Mary Cushman
,
J. Danesh
,
DPhil FMedSci
,
MD Stéphanie Debette
,
Peter J Duggan
,
P. Durda
,
P. G. Engstrom
,
P. Enzinger
,
MD Jessica D Faul
,
Mph Israel Fernández-Cadenas
,
Peter C. Geiger
,
P. Giese
,
M. Grewal
,
MD Ulrike Grittner
,
PhD Aki S. Havulinna
,
DSc Laura Heitsch
,
Marc C. Hochberg
,
M. Holliday
,
Ping Hu
,
PhD Marguerite R. Irvin
,
MD Rebecca D. Jackson
,
MD Mina A. Jacob
,
Raquel Rabionet Janssen
,
MD PhD Jordi Jiménez-Conde
,
PharmD Julie A. Johnson
,
MD PhD Yoichiro Kamatani
,
PhD Sharon L. R. Kardia
,
PhD Masaru Koido
,
MD Michiaki Kubo
,
P. Lange
,
P. J. Lee
,
PhD Robin Lemmens Md
,
PhD Christopher Levi
,
B. S. Mbbs
,
Fahms Jiang Li
,
PhD Li
,
M. Lin
,
Priscilla Lopez
,
B. Luke
,
Mph Jane Maguire
,
BA RN Patrick F. McArdle PhD BNurs
,
Patrick McDonough
,
PhD James F. Meschia
,
MD Tiina Metso
,
Phil O'Connor
,
P. O’Donnell
,
PhD Leema
,
Mbbs Reddy Peddareddygari
,
Meritxell Pera
,
Peter J. Perry
,
P. Peters
,
PhD Jukka Putaala
,
P. Ray
,
PhD Kathryn Rexrode
,
Mph Marta Ribases Md
,
M. P. C. Md
,
FMedSci Tatjana Rundek PhD
,
F. K. A. PhD
,
M. Sacco
,
M. F. E. Md
,
P. G. Md
,
Bsc Phd
,
MD Pankaj Sharma
,
Frcp Agnieszka Slowik PhD
,
M. M. PhD
,
PhD Martin Soderholm
,
PhD O. Colin Stine
,
PhD Daniel Strbian
,
Msc Phd
,
F. DPhil
,
PhD Chikashi Terao
,
PhD Vincent Thijs
,
PhD Nuria P. Torres-Aguila
,
PhD David-Alexandre Trégouët
,
Pandey Anil
,
MD PhD Man Tuladhar
,
MD Jan H. Veldink
,
PhD Robin G. Walters
,
PhD David R. Weir
,
MD Daniel Woo
,
M. B. B. Worrall
,
M. C. C. Md
,
Philipp. Ross
,
PhD Ramin Zand
,
Mph F-E De Leeuw Md
,
Pâmela Paré
,
F. Anderson
,
M. H. S. Md
,
M. Jern
,
Priya Md
,
PhD Martin Dichgans
,
M. D. Mitchell
,
M. PhD
,
O. Stine
· 0 min read
Abstract
Abstract Objective: To determine the contribution of common genetic variants to risk of early onset ischemic stroke (IS). Methods: We performed a meta-analysis of genome-wide association studies of early onset IS, ages 18-59, using individual level data or summary statistics in 16,927 cases and 576,353 non-stroke controls from 48 different studies across North America, Europe, and Asia. We further compared effect sizes at our most genome-wide significant loci between early and late onset IS and compared polygenic risk scores for venous thromboembolism between early versus later onset IS. Resul…
Type
Publication
medRxiv