@article{jaworek2021genetic,
 abstract = {Abstract Objective: To determine the contribution of common genetic variants to risk of early onset ischemic stroke (IS). Methods: We performed a meta-analysis of genome-wide association studies of early onset IS, ages 18-59, using individual level data or summary statistics in 16,927 cases and 576,353 non-stroke controls from 48 different studies across North America, Europe, and Asia. We further compared effect sizes at our most genome-wide significant loci between early and late onset IS and compared polygenic risk scores for venous thromboembolism between early versus later onset IS. Resul...},
 author = {MS Thomas Jaworek and MD Huichun Xu and P. Gaynor and M. Cole and MS Kristiina Rannikmäe Md and Priya Md and PhD Liisa Tomppo and Priya Md and P. Amouyel and P. N. D. Armstrong and MS John Attia PhD and Frcpc Fracp Clin Dip PhD and Palliat Med and PhD Steven Bell and MD Oscar R. Benavente and MD Giorgio B. Boncoraglio and PhD Adam Butterworth and MSc Jara Cárcel-Márquez and Zhengming Chen and MSc Michael Chong and PhD Carlos Cruchaga and MSc Mary Cushman and J. Danesh and DPhil FMedSci and MD Stéphanie Debette and Peter J Duggan and P. Durda and P. G. Engstrom and P. Enzinger and MD Jessica D Faul and M. PhD and Mph Israel Fernández-Cadenas and Peter C. Geiger and P. Giese and M. Grewal and MD Ulrike Grittner and PhD Aki S. Havulinna and DSc Laura Heitsch and Marc C. Hochberg and M. Holliday and Ping Hu and Priya Md and PhD Marguerite R. Irvin and MD Rebecca D. Jackson and MD Mina A. Jacob and Raquel Rabionet Janssen and MD PhD Jordi Jiménez-Conde and PharmD Julie A. Johnson and MD PhD Yoichiro Kamatani and PhD Sharon L.R. Kardia and PhD Masaru Koido and MD Michiaki Kubo and P. Lange and P. J. Lee and PhD Robin Lemmens Md and PhD Christopher Levi and B. S. Mbbs and Fahms Jiang Li and PhD Li and M. Lin and Priscilla Lopez and B. Luke and Mph Jane Maguire and BA RN Patrick F. McArdle PhD BNurs and Patrick McDonough and PhD James F. Meschia and MD Tiina Metso and Priya Md and Phil O'Connor and P. O’Donnell and PhD Leema and Mbbs Reddy Peddareddygari and Meritxell Pera and Peter J. Perry and P. Peters and PhD Jukka Putaala and P. Ray and PhD Kathryn Rexrode and Mph Marta Ribases Md and Bsc Phd and M. P. C. Md and FMedSci Tatjana Rundek PhD and F. K. A. PhD and M. Sacco and M. F. E. Md and P. G. Md and Bsc Phd and MD Pankaj Sharma and Frcp Agnieszka Slowik PhD and Priya Md and M. M. PhD and M. PhD and PhD Martin Soderholm and PhD O. Colin Stine and PhD Daniel Strbian and Msc Phd and F. DPhil and PhD Chikashi Terao and PhD Vincent Thijs and PhD Nuria P. Torres-Aguila and PhD David-Alexandre Trégouët and Pandey Anil and MD PhD Man Tuladhar and MD Jan H. Veldink and PhD Robin G. Walters and PhD David R. Weir and MD Daniel Woo and M. B. B. Worrall and M. C. C. Md and Philipp. Ross and PhD Ramin Zand and Mph F-E de Leeuw Md and Priya Md and Pâmela Paré and F. Anderson and M. H. S. Md and M. Jern and Priya Md and PhD Martin Dichgans and M. D. Mitchell and M. PhD and O. Stine},
 doi = {10.1101/2021.11.06.21265795},
 journal = {medRxiv},
 title = {Genetic Contributions to Early and Late Onset Ischemic Stroke},
 year = {2021}
}