Origin, Evolution, and Functional Impact of Short Insertion- Deletion Variants in Human Genomes: A Review

Repetitive DNA is now recognised as crucial components of the genome landscape of several eukaryotes. The Short insertions and indels class of repetitive DNA account for approximately 12% of all variations in the human genome. Their unique genome organisation and architecture confer the DNA several unique characteristics which are avenues for DNA biophysical and gene regulation studies. Further, given their frequent occurrence in the genome they are used in several genome mapping efforts. The present review is an update on the indel variation in the human genome covering diverse section on the…