An update on the Genetics, Cellular and Evolutionary Implications of X Chromosome Demasculinization

Sex chromosomes and autosomes evolve in different trajectories depending on gene expression during gametogenesis. The X chromosome gene content across animal taxa shows opposite tendencies in different species implicating the underlying genetic basis of adaptive changes. The constraints imposed on the X chromosome by meiotic sex chromosome inactivation (MSCI) and related spermatogenesis-specific regulatory processes underscore the dynamic interplay between developmental regulation and evolutionary adaptation. The ying–yang functions of MSCI results in distinctive genomic architecture in which …